MONEY!!. She seems to be feeling better but still very concerned of why these levels are still up. Don't trust your vet, do your own research. Her poor top underside of her tail has raw skin the hair is completely gone like burnt off from diarrhea. Just gave this to my 2 year old 77 lb boxer 5 hours ago and I'm SCARED! She had some good days and we were hopeful but ultimately, she steadily declined. He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. Those jaw spasms have decreased but were pretty alarming in Dec and January. I check this thread regularly and Im sooo grateful to all who wrote. CET HEXtra Chews. Our 9 month 5lb Morkie was prescribed this garbage and we noticed the shakes, his lower lip quivering, and he looks around as if an invisible fly is flying around his head. She does have history of seizures. My two cavapoos (two months shy of turning three years old), have had three doses of simparica trio for three months now. Now his tail looks like a rat tail. He has been eating the same organic GF food for the past several years. Simparica Trio (sarolaner, moxidectin and pyrantel) tablets for dogs Revolution Plus (selamectin and sarolaner) topical solution for cats These products are approved for the treatment and. Gave my dog Charlie Simparica yesterday now he is shaking and panting really bad. Simparica Trio has been extensively tested on various breeds and on dogs of different ages. He had an MRI and it came out good. This is worth the cost to buy a six-pack of protection. I gave this to my 8 yr old chihuahua and a couple days later he started having seizures. Normal. Still waiting on the vet and waiting to talk to ASPCA poison control. When GABA attaches to a protein in your brain known as a GABA receptor, it produces a calming effect. She was shaking like she was freezing. And yeah he ate today 4 chicken breast and appeared to want it even better. He had been on it for 4-5 months . Good bless you all. I'm so sorry. I have my 14 week old pup simparica (vet recommended) 2 days ago. My chihuahua is 18 days since the last seizure episode, she is finally playing again but I'm noticing her shaking her head on the left side and it's very odd. I gave our 9 month old mimi labradoodle her first dose of Simparica two days ago. I to also gave my best friend Simparica as recommended by the vet. There is also a chance that hell need a surgery. Simparica Trio Recall can be trusted with their product. Our dog has had 2 Seizures this month and we are going to stop using Simparica. Side effects are rare and may include: Neurologic side effects have been seen after using medications in this class of drugs. It definitely can cross blood brain barrier and cause other neurological issues so it makes sense it could do this too, but clearly they havent done enough research to understand how. They have become so bad that she cries and whimpers any time she is laying down. The following day he died. I would say these changes may have happened more suddenly than just normal aging so I'm not going to give him this medication anymore. Im still confused. He had to be put to sleep and Im devastated. the first puppy was still born looks to have died younger .my assumption when I gave lola that pill.she lost 1 puppy .the second baby is doing okay.although the vet said watch for neurological problems and GI problems. My dog is 9 yrs old . No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. I have another dog, but gave him Frontline and he's fine. That was when I lived in Fort Lauderdale. Simparica Trio does cover more but after reading both I've decided to use Revolution. Doesn't anyone here wonder why?, if this is sooo safe to use with mammals, isn't there a human version also available? On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. After being ingested by a dog, sarolaner is distributed throughout the body. This drug has caused our dog to loose his footing and not eat. Simparica is approved for dogs and puppies weighing more than 2.8 pounds and over 6 months of age. I feel so sad for you Camelia. So I started searching and came across this blog and my heart just sank. We did a cortisone pack to help him manage his "arthritis" symptoms that I totally feel were related to the simparica. before i even gave to my dog small doxie i asked the vet about it and they assured me it was safe since she was and i say was a healthy dog. Vet said they dont think it has anything to do with the Simparica. He already has canine dementia on and off. I am more than upset, I am effing pissed, my poor little boy. Tuesday morning she woke up with horrible diarrhea. He never ever used to do this. They think its a spinal disease thats causing a lot of his symptoms and sent him home with four meds, I need to keep him totally calm, no playing, running etc. She vomited twice and became so lethargic that she couldnt walk. He doesn't seem to be throwing up as much anymore, he did several times throughout the night though. Well, let me tell you: THANK YOU ALL FROM THE BOTTOM OF MY HEART. As per chewable tablets, this medicine is safe for all breeds of dogs. He is sometimes picky with his food, so I mixed in some green beans, etc but he stopped eating anything and had bright orange diarrhea by the 31st. My dog has had a previous back leg surgery. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. We were told the Neurologist would be between $10,000 to $12,000. Simparica Trio contains three active ingredients . Currently, for Simparica, less than 0.01% of dogs taking this medication have experienced any neurologic side effects. Thankfully I have had experience with dealing with this with my kids and relatives so I dosed him with Benadryl. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. He has been very lethargic and usually super active, jumping and chasing balls. now almost exactly two months later, sick again with a fever and stops eating. I called the vet and they said it was likely brought on by stress. Instead, it kills larvae, allowing your dog to avoid infection. My baby is so sick from this Drug. I threw him his ball and he actually was interested in it. First time for this adverse reaction. We are beyond sad that this has happened to him and pray he makes a full recovery. I will never give my dog this medication again. I have been feeding her some white rice hoping it improves. I am SOOO angry! Today she has fallen 2 or 3 times in the last 8 hours). They had no clue what had happened so again we took him to the er and he checked out fine. Simparica has a low incidence of seizures but still the FDA made the company include the warning. In our case the damage was permanent. That is the only thing that has changed in her routine. its been 2 weeks .We just had a blood draw done again and they are still high. My 2 1/2 mini goldendoodle has been on Simparica 10 days now. After he was sent home, he was still not well and barely able to hold in any food and had to take any fluids intravenously. ALL oral tick meds are in the same class of drugs, so cannot give anything with that in it. After reading all your entries, i'm thrilled i chose to take her off of it. Did you do this yourself or let the vet? My vet never informed me of any issues with this medication and I'm kicking myself hard now after reading all of these horrible experiences with everyone's fur companions. I just hope he has a turn around . So sorry you are having to go through this! We gave our 13 yr old lab mix this medicine as our doctor doesn't carry trifexis anymore. Thanks Michelle! Shes not the carefree setter she was prior to this medication. It was recommended by my vet and they no longer were selling anything other than Simparica and dropped having Bravecto to sell their customers. Your veterinarian is the best source of information and will help you choose the right product for your dog and your budget. I hope I have found the culprit to his digression. But now I'm almost convinced that they could have been seizures, and I just pray that they weren't, and pray that he doesn't have to experience anymore troubles. Today started diarrhea & he has gone 5 times so far while not eating much. Then he starts scratching and as time goes on he seemed like something was wrong. If not, we had some success with symptom management using Prednisone. All went well until this morning. I notified my vet and Zoetis, the company that makes this drug. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. I would not recommend giving Simparica to your pets!!!!! Did the tremors ever stop? So far, the cost of diagnostic tests are about $700. Very small sample - many deformities, stillborn. I wish I had seen this post first. I've tried Gatorade and Ginger ale but he only drank a little. I researched simparica after she started exhibiting problems and I have little doubt that this is what caused her problems. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Saturday he started up the drinking again and threw up his breakfast. My pup is scheduled to see a neurologist Monday ( today's friday) to evaluate. If so how long did it take? Hi, Id like to thank all the contributors to this thread and Im so very sorry for the pain you and your pets have undergone. Not known if there be permanent after-effects. Another difference is flavor. At the same time, Simparica Trio is used to prevent heartworm and lungworm disease (both caused by blood worms that infect the heart and blood vessels supplying the lungs). Since she is young, the vet started us with Keppra. Thannks !! Doing better now, 2 days later. Im certain that its the simparica. Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. How is your puppy doing? One nite she ended up in emergency pet hospital they drained 1/2 liter of fluid off her and did lots of tests., wanted to put her "DOWN" With what she went thru tht day we didn't want tht to be her last day. Hi Charlene, can you elaborate on agitated swallowing? Simparica Trio works to prevent heartworm disease, treat and prevent flea infestations, treat and control tick infestations, and treat and control roundworms and hookworms. Ours lasted about a week. I let him back in the bedroom yesterday all went well, then this morning I woke to him peeing in the floor again. I gave it to her then I looked at the box that said never tested on pregnant dogs . Made the pressured in to by a vet to give Simparica Trio. Went to a different vet, within minutes he found a large mass on my Poms abdomen. Read the package insert and it does list tremors and seizures as a side effect. This happened to our 2yr old frenchie last Friday. In clinical trials, vomiting and diarrhea were the most frequently reported adverse reactions. I am terrified--wish I would of seen this sooner. The only thing the vet can say, was a sore neck. He is eating fine with no diarrhea or vomiting. I want to cry I wish I could get it out of her system after reading these comments. Is it effective? My vet prescribed my 16 week old puppy this drug because of a skin irritation. Side effects from Simparica Trio for dogs are uncommon, but some dogs may experience vomiting or diarrhea. Another possibility would be that the dosage was to high for her (simparica comes in three different dosages). Does any one think this could be a reaction to Simparico Trio? This is terrible. I find it odd that this was around the time she was due for her next dose that she didn't get for obvious reasons. No side effects. How long did the itching last with your pet. She has NEVER done that before. Twice I have seen his eyes roll into the back of his head (petti-mal seizure?) With the March 1 dose, on that day, I noticed him seeming to be very fearful and flinching on several occasions. These include vomiting, diarrhea, lethargy, inappetence, itching, and, very . Follow the directions on the drug label for Simparica or Simparica Trio or as provided by your veterinarian. $37.98 with Subscribe & Save discount. Currently we are monitoring him closely-hes never been sick. Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. Simparica has possibly shown no severe side effects that may concern the health of dogs. The next day she had diarrhea. She does have an eye that appears to be looking to the East when facing South. It is the most convenient flea and tick protection product on the market. Humans are another matter. Its crazy to think they dont recover and can die in a few months. The vet does not feel it is due to Simparica but i think it could be. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. Our pick for best oral flea control product for dogs is Simparica TRIO, a chewable tablet that is fast-acting and kills more parasites than any other oral product. It seemed impossible that our boy could age years in literally 3 days. I just wanted to get another opinion before we move forward. By Tuesday evening symptoms came back worse. I am giving her supplements to support her heart and nerves and she's a little better each day. My 14 year old, 3.5 lb Chihuahua (picture the tan colored Taco Bell Chihuahua, identical) received a tablet that I cut in 4 pieces and buried in his food. His motor skills have been affected and hes been losing weight even though he eats heartily. The next morning, she had uncontrollable tremors and could not walk without falling down. They may not be ready to beat you in a game of chess, but these brainy dogs are easy to train and generally eager to please you. , for Simparica or Simparica Trio has been on Simparica 10 days now of water then... Three different dosages ) seemed impossible that our boy simparica trio for dogs side effects age years in literally 3 days we had good. Sleep and Im devastated i 've tried Gatorade and Ginger ale but he only drank little... 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